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Neurobiology of Drug Addiction [+]

Visiting Professor Mervyn Alleyne [+]

UPR Artist's Mosaic Caps Train Station [+]

Debates on Multidisciplinary Studies and Science [+]


Neurobiology of Drug Addiction

by Javier Ortiz

IS DRUG ADDICTION genetically determined or a learned behavior? It's both, says Carmen S. Maldonado, Ph.D., a biologist at the University of Puerto Rico, Río Piedras. That's why pharmacology and psychology both play a role in successfully treating addiction.

"This is one of the biggest controversies in the discipline: what controls what? Many factors are involved, and biology is one of them, but environment must also fit into the equation," says Maldonado.

Based on that hypothesis, Maldonado applies the concept of operant conditioning from behavioral psychology in laboratory experiments with rats. In this way, she shows that drug addiction is also a learned behavior.

"Precisely due to the pleasurable, positive experience, a connection is established with memories associated with the experience. These memories become relevant during the entire addictive experience."

This is why, despite detoxification, many people fall back into addictive behavior when they return to an environment associated with drug consumption. "It's not that the substance is in the body. It's the absence of the substance in the presence of environmental stimuli that causes the return to addiction."

With the help of a group of students in her laboratory, Maldonado identifies possible molecular, cellular, and neurochemical agents that combine in the brain to produce this learned behavior. Once these agents are recognized, pharmacology is applied to interfere with them and block their action.

In the rats, Maldonado found that after inhibiting the protein Kinase C (associated with memory) there were no recurrences in addictive behavior. Likewise, pharmacological incapacitation of neurotensin–the neuropeptide that modulates the chemical released in the brain when pleasure is produced–prevents relapse when a person is exposed to the environment associated with drug consumption.

The next step in this research is to determine the genetic profile of addiction. "The human genome was recently decoded, and at the beginning in the 21st century, there is great interest in decoding the genes that control behavior."

In our society, drug addiction is commonly criminalized, and this carries a considerable amount of social stigma. The clear failure of this strategy makes it necessary to explore new perspectives.

"Addiction is truly a medical problem, not an issue of personality or of lack of strength or character. When society accepts this reality, the stigma of the addict will go away, and the addict will be able to better function in society."


Visiting Professor Mervyn Alleyne

by Suzanna Engman







"Language-status change happens when people become conscious of their own worth, when the democratization process matures and the notion of equality becomes more dominant."

IF LANGUAGES WERE COLORS, the Caribbean would be a rainbow. English, Spanish, French, Dutch, African languages and a whole spectrum of Creoles are spoken within its arc of islands. Linguistics, a cognitive science that draws from history, sociology, psychology, physics, physiology, geography, anthropology, literature, and political science, finds a wealth of data here.

Visiting professor Mervyn Alleyne, a linguist at the University of the West Indies in Jamaica, is researching and teaching at the University of Puerto Rico, Río Piedras for the 2003-2004 academic year. As a dialectologist, Alleyne studies language variation: how languages were formed, how they change, and why they change.

"Different dialects of the language have different prestige levels. One may say that there is a hierarchy of cultures. We also have a hierarchy of languages. Certain forms of speech are considered better, more elegant. But relationships between dialects have changed and are changing.

"Today, groups which have long been stigmatized for their speech are discarding some of the negative values which have been assigned to their forms of cultural behavior, including language. Language-status change happens when people become conscious of their own worth, when the democratization process matures and the notion of equality becomes more dominant. I'm interested in how the oppressed Creole languages of the Caribbean are struggling to gain recognition after centuries of stigmatization."

Alleyne offers evidence of language-status change in the Caribbean: "In the Netherland Antilles the Papiamento language [a Creole] has become a co-official language with English and Dutch. It's becoming widely used in literature. There are also signs, for example in Haiti and Martinique-Guadeloupe, that French Creole is being used in scientific discourse. Usually science is considered to be the highest point that a language can achieve in its development because only the most highly educated people use scientific language. It is associated with intellectual activity."

Visiting Professor Mervyn Alleyne is the author of The Construction and Representation Race and Ethnicity in the Caribbean and the World(2002), Syntax Historique Creole(2000), and Roots of Jamaican Culture (1997).


UPR Artist's Mosaic Caps Train Station

by Suzanna Engman



Fine Arts Professor Nathan Budoff with his students.




"I wanted people to think about what it means to be in the Caribbean–in Puerto Rico–to remind them that there is something that's really wonderful about it."

IF YOU LOOK UP in the Martínez Nadal Train Station, you'll be transported into a rainforest fantasy. The scene: a man with a billowing raincoat losing his grip on his briefcase and ascending into a blue, blue sky. He is surrounded by green parrots and tropical foliage.

"I wanted to leave it open-ended, attractive enough to generate interest and open to a number of possible interpretations," says Nathan Budoff, artist, Fine Arts professor of University of Puerto Rico, Río Piedras, Fullbright scholar, author, translator, doctoral candidate in Caribbean literature, and creator of the mosaic Con las cotorras ("With the Parrots").

The $316,000 public art project begun in 2002 now crowns the ceiling of the new Tren Urbano station in Guaynabo. Budoff hopes the 43-foot-diameter mosaic will remind commuters that we live in the Caribbean. "It's a comment about contemporary society's relationship to nature, or lack thereof. We live here and the way we live we could be living almost anywhere. I wanted people to think about what it means to be in the Caribbean–in Puerto Rico–to remind them that there is something that's really wonderful about it."

The project began as a 7-foot diameter painting. It drew Budoff into the Caribbean National Rainforest, El Yunque, to research the endangered Puerto Rican parrots he depicts and to a small town about an hour away from Venice, Spilimbergo, where the finest mosaic artists in the world have practiced the art of fabricating mosaics for generations.

Each piece of colored glass is about one-half by three-eighths of an inch. It took the Spilimbergo artisans three months to glue, piece by piece, the hundreds of thousands of glass pieces comprising the mosaic onto two-foot-square pieces of paper, forming a mirror image of the mosaic. The artisans also created a map of the two-foot-square sections so that they could correctly mount them in cement in Puerto Rico. Once a section was secured to the ceiling, the paper was removed and each of the pieces was adjusted to eliminate any seams or lines. Because of the strategic planning, the actual installation of the mosaic took only three weeks.

As the painting evolved into a mosaic, Budoff added foliage and changed some details. For example, when viewing Puerto Rican parrots up close in the Puerto Rican Parrot Recovery Program aviary at El Yunque, he noticed some blue feathers in their wings. The parrots in the painting did not initially have these blue wing feathers, so he added them during a later stage of development.

The close-to-complete Tren Urbano project includes 10.7 miles of track and 16 train stations. Each station features at least one piece of art commissioned by the Proyecto de Arte Público de Puerto Rico. Con las cotorras is one of several mosaics.

http://www.artepublico.puertorico.pr


Photos of some sections of Con las cotorras, a mosaic on the ceiling of Martínez Nadal Train Station.



Debates on Multidisciplinary Studies and Science

by Javier Ortiz

AFTER SEVERAL YEARS of experimenting with multidisciplinary research, the time has come to critically reflect on this approach. At least that's what members of the Cyber Network of Transdisciplinary Studies think, as they invite the academic community to "Boundaries and Membranes: Disciplines and Possible Conditions of Transdisciplinary Work, " their second seminar on science and knowledge.

According to Emilio González, Ph.D., director of the project and the Social Science Research Center at the University of Puerto Rico, Río Piedras, the seminar proposes to reach beyond multidisciplinary approaches to focus specifically on the question of boundaries between disciplines. Do boundaries separate or are they membranes that communicate? How open are our academic and scientific institutions to this type of work? And perhaps a more fundamental question: What advantages can the transdisciplinary perspective contribute to more traditional perspectives?

ReCiT (the Cyber Network's Spanish acronym) is Web site linking a network of researchers to discuss transdisciplinary approaches to knowledge. The researchers hope their Internet tool facilitates dialogue about various approaches to scientific studies and promotes multidisciplinary collaborations. In González' words, "the idea of this project is to create a network of people from various disciplines who are interested in developing research that contributes to the views of their discipline yet goes beyond what their discipline defines."

ReCiT first emerged in February 2001 as a result of the seminar "Contemporary Debates on Science and Knowledge: A Multidisciplinary Approach." During nine weeks of study on topics from a wide range of disciplines, the participants debated the production of knowledge, the meaning of knowledge, and the privileged status of scientific knowledge.

Works in physics, psychology, ecology, architecture, philosophy and biology, among other disciplines, were discussed in the seminar, and these topics continue to be debated on the ReCIT Web site, designed by graduate alumnus Rafael Texidor.

http://recit.rrp.upr.edu


   
     
 

 

 

 

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